Having been misdiagnosed with Bipolar II, and later with premenstrual dysphoric disorder (PMDD), Waldman begins her book at a point where all her remedies for depression and mood swing have essentially failed her. She has stumbled across the book The Psychedelic Explorer's Guide: Safe, Therapeutic, and Sacred Journeys by James Fadiman. Waldman, a previous federal public defender and law professor who taught “The Legal and Social Implications of the War on Drugs” at UC Berkeley, is also the mother of four. Disturbed by the impact of her emotional instability on her family, she begins taking microdoses of LSD following Fadiman’s protocol. Having no interest in an LSD prompted spiritual enlightenment or hallucinatory experience; she is motivated instead to join Fadiman’s experiment by the outcomes described by others who have participated: namely more positive mood and increased ability to focus.
A Really Good Day, is written as an amusing daily journal of her experience “microdosing” which she intersperses with the compelling story of LSD as a pharmaceutical and then social drug. She is forthright in her concerns regarding the use of LSD as an illegal substance and hiding this use from her children, and her internal conflict with taking what is perceived to be a “recreational” drug. Waldman explores the effects of microdosing on depression and anxiety through her witty and deeply personal disclosure, which she balances with a rich and informative history of LSD. Her skepticism, overcome by self-described “desperation” for “A Really Good Day” is met with outcomes that are surprising and provocative.